Richard A Messmann Selected Research

EC145

12/2013	PRECEDENT: a randomized phase II trial comparing vintafolide (EC145) and pegylated liposomal doxorubicin (PLD) in combination versus PLD alone in patients with platinum-resistant ovarian cancer.
11/2012	Phase I study of folate conjugate EC145 (Vintafolide) in patients with refractory solid tumors.
10/2012	Multicenter trial of EC145 in advanced, folate-receptor positive adenocarcinoma of the lung.
2/2011	Reducing undesirable hepatic clearance of a tumor-targeted vinca alkaloid via novel saccharopeptidic modifications.
12/2009	Clinical pharmacokinetics and exposure-toxicity relationship of a folate-Vinca alkaloid conjugate EC145 in cancer patients.

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Richard A Messmann Research Topics

Disease

11	Neoplasms (Cancer) 01/2017 - 02/2003
2	Ovarian Neoplasms (Ovarian Cancer) 12/2013 - 11/2012
2	Ovarian Epithelial Carcinoma 12/2013 - 11/2012
2	Constipation 02/2011 - 12/2009
1	Prostatic Neoplasms (Prostate Cancer) 01/2021
1	Inflammation (Inflammations) 01/2017
1	Non-Hodgkin Lymphoma (Lymphosarcoma) 07/2014
1	Burkitt Lymphoma (Burkitt's Lymphoma) 07/2014
1	Lymphoma (Lymphomas) 07/2014
1	Melanoma (Melanoma, Malignant) 07/2014
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 11/2012
1	Adenocarcinoma of Lung 10/2012
1	Adenocarcinoma 10/2012
1	Fatigue 02/2003
1	Diarrhea 02/2003
1	Pain (Aches) 02/2003
1	Fever (Fevers) 02/2003

Drug/Important Bio-Agent (IBA)

6	Folic Acid (Vitamin M)FDA LinkGeneric 12/2013 - 06/2008
5	EC145IBA 12/2013 - 12/2009
3	Pharmaceutical PreparationsIBA 01/2017 - 02/2003
3	AlkaloidsIBA 11/2012 - 12/2009
2	Proteins (Proteins, Gene)FDA Link 01/2017 - 02/2003
2	PNT100IBA 07/2014 - 02/2014
2	DNA (Deoxyribonucleic Acid)IBA 07/2014 - 02/2014
2	HydrazinesIBA 11/2012 - 12/2009
2	alvocidib (flavopiridol)IBA 02/2003 - 02/2003
1	Gallium-68IBA 01/2021
1	PSMA-11IBA 01/2021
1	taxaneIBA 01/2021
1	Androgen Receptors (Androgen Receptor)IBA 01/2021
1	AntigensIBA 01/2021
1	177Lu-PSMA-617IBA 01/2021
1	Antineoplastic Agents (Antineoplastics)IBA 01/2017
1	Transcription Factors (Transcription Factor)IBA 01/2017
1	NF-kappa B (NF-kB)IBA 01/2017
1	EndonucleasesIBA 01/2017
1	1-dodecylpyridoxal (PLD)IBA 12/2013
1	liposomal doxorubicin (Doxil)FDA Link 12/2013
1	PlatinumIBA 12/2013
1	LigandsIBA 11/2012
1	EC 0489IBA 02/2011
1	Protein Isoforms (Isoforms)IBA 06/2008
1	7-hydroxystaurosporine (UCN 01)IBA 10/2004
1	Acute-Phase Proteins (Acute-Phase Protein)IBA 02/2003

Therapy/Procedure

4	Therapeutics 01/2021 - 11/2012
1	Castration 01/2021
1	Intravenous Injections 11/2012
1	Drug Therapy (Chemotherapy) 10/2012